Having played a second game against Pandora with Perdita (Francisco, Santiago & the Executioner 20SS), I gotta say she's not that hard to run.
Maybe Perdita just doesn't do well against her, but you can't just sit back and shoot away. Self-Loathing has a Range of 12, and the longest gun is Nino's at 16, the rest of the Ortegas is 10. So he can pop off a couple wounds on you before you get a shot. And anytime you fail that WP test, you take a wound, and often have to fall back 4" Pandora also negates Perdita's Immune to Influence.
Sonnia and her crew may fare better, but a straight up gunline isn't an auto win.