This is all theoryfaux, but hang with me. This is going to be a wild ride.
The way I see it, Lucius has three good things about his matchup into nexus.
1. Decent protection from the initial parasite push.
Many of lucis crew are either disguised or can put attackers on negatives, which will make the nests have a hard time getting that first pinning parasite off. And lucius crews have decent wp and good card draw to handle the simple duels that lead to parasites, and shielded from the lawyers can help with that too.
2. Pass tokens let lucius get cards.
Does your opponent want to summon 3 e&e? Sure go ahead, but lucius will get cards from it. When he uses the pass tokens.
3. Misinformation is great against low wp.
Especially ones that want to get in your face.
4. Lucius can use hidden sniper to attack those key hard to reach models.
I'm not sure this pays off, but I feel like luci could really pressure nexus herself and meredith with some hidden sniper shots.
I'm not sure that's enough to deal with what cadmus is cooking but it might be worth a try.
I've also been giving some thought to greed, which is just horrifying, and the undercover reporter, which I don't hate.