In the game I'm running now, the Fated are stuck between the Guild and 10T in a noir style investigation. They work well as foils to put the screws to them, as an Elite division agent is never far from their heels. But, since they're so all encompassing, they're also constantly vexed by a guild detective who actually is a good guy and has caught a whiff of their corruption. It's fun having different faces of the same organization twisting them up from both ends.